Article

Autophagy Dysfunction in iPSCs-Derived Neurons and Midbrain Organoids Carrying a <i>SNCA</i> Triplication

2025-08-08

Abstract excerpt

Parkinson’s disease (PD), characterized by α-Synuclein aggregation and dopaminergic neuronal loss, has no current cure. Autophagy is critical for α-Synuclein clearance, yet its real-time dynamics remain challenging to assess in human-relevant systems. Here, we used live-cell imaging to assess autophagy within human neuronal cultures and midbrain organoids (hMOs) derived from induced pluripotent stem cells (iPSCs)...

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Literature Corpus work: 7b86ff66-9778-5c5d-a1a6-1f2fb566e702
DOI: 10.1101/2025.08.08.669314

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