Article
The epigenomic landscape regulating organogenesis in human embryos linked to developmental disorders
2019-07-03
Abstract excerpt
How the genome activates or silences transcriptional programmes governs organ formation. Little is known in human embryos undermining our ability to benchmark the fidelity of in vitro stem cell differentiation or cell programming, or interpret the pathogenicity of noncoding variation. Here, we studied histone modifications across thirteen tissues during human organogenesis. We integrated the data with transcriptio...
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Identifiers and source
- Literature Corpus work
- 22127372-700d-524c-9022-d9427e21ddb7
- DOI
- 10.1101/691766