Article
Dynamic changes in the epigenomic landscape regulate human organogenesis and link to developmental disorders.
Nature communications - 6 Aug 2020
Gerrard Dave T, Berry Andrew A, Jennings Rachel E, Birket Matthew J, Zarrineh Peyman, Garstang Myles G, Withey Sarah L, Short Patrick, Jiménez-Gancedo Sandra, Firbas Panos N, Donaldson Ian, Sharrocks Andrew D, Hanley Karen Piper, Hurles Matthew E, Gomez-Skarmeta José Luis, Bobola Nicoletta, Hanley Neil A
Abstract excerpt
How the genome activates or silences transcriptional programmes governs organ formation. Little is known in human embryos undermining our ability to benchmark the fidelity of stem cell differentiation or cell programming, or interpret the pathogenicity of noncoding variation. Here, we study histone modifications across thirteen tissues during human organogenesis. We integrate the data with transcription to build...
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