Article

Large Serine Integrase Off-Target Discovery with Deep Learning for Genome Wide Prediction

2024-10-13

Abstract excerpt

Large Serine Integrases (LSIs) hold significant therapeutic promise due to their ability to efficiently incorporate gene-sized DNA into the human genome, offering a method to integrate healthy genes in patients with monogenic disorders or to insert gene circuits for the development of advanced cell therapies. To advance the application of LSIs for human therapeutic applications, new technologies and analytical met...

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Literature Corpus work: 1450a7cb-6760-5490-95ce-1882bf7fbb65
DOI: 10.1101/2024.10.10.617699

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