Article

Embryonic Stem Cell-Specific Responses to DNA Replication Stress

2025-05-18

Abstract excerpt

Genome maintenance is of the utmost importance in stem cells, as mutations can be propagated and cause defects in derivative tissues. Many stem cell types display low mutation rates, with embryonic stem cells (ESCs) being a notable example. The bases for this property are unclear but may be achieved by optimization of various processes including high-fidelity DNA repair, cell cycle checkpoint controls, and hyperse...

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Literature Corpus work: 8a42f65b-da41-5d3f-8bb1-3f406f59d319
DOI: 10.1101/2025.05.16.654332

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