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Article

Early cellular mechanisms of type I interferon-driven susceptibility to tuberculosis

28 Nov 2023

Abstract excerpt

Mycobacterium tuberculosis (Mtb) causes 1.6 million deaths annually. Active tuberculosis correlates with a neutrophil-driven type I interferon (IFN) signature, but the cellular mechanisms underlying tuberculosis pathogenesis remain poorly understood. We found that interstitial macrophages (IMs) and plasmacytoid dendritic cells (pDCs) are dominant producers of type I IFN during Mtb infection in mice and non-human...

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PMID: 38029747
DOI: 10.1016/j.cell.2023.11.002

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