Article

Illuminating host-mycobacterial interactions with functional genomic screening to inhibit mycobacterial pathogenesis

2020-03-31

Abstract excerpt

<h4>SUMMARY</h4> Existing antibiotics are inadequate to defeat tuberculosis (TB), a leading cause of death worldwide. We sought potential targets for host-directed therapies (HDTs) by investigating the host immune response to mycobacterial infection. We used CRISPR/Cas9-mediated high-throughput genetic screens to identify perturbations that improve the survival of human phagocytic cells infected with Mycobacteri...

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Literature Corpus work: bddd2eb0-61b5-5982-bd62-dc1c2e3fb29c
DOI: 10.1101/2020.03.30.016139

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