Article

CMPK2 restricts <i>Mycobacterium tuberculosis</i> replication and regulates macrophage gene expression

2026-05-21

Abstract excerpt

Host cell metabolic pathways influence innate immune responses to intracellular pathogens, but the contribution of nucleotide metabolism to antimicrobial defense remains incompletely defined. Here, we identify the mitochondrial nucleoside monophosphate kinase CMPK2 as a regulator of macrophage responses to Mycobacterium tuberculosis (Mtb). Using a targeted genetic screen of candidate host factors, we found that d...

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Literature Corpus work: bcfa570a-f8ab-5765-9755-a204b7d230f5
DOI: 10.64898/2026.05.19.726211

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