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Article

Type I IFN signaling in the absence of IRGM1 promotes <i>M. tuberculosis</i> replication in immune cells by suppressing T cell responses

2023-10-05

Abstract excerpt

<h4>ABSTRACT</h4> Polymorphisms in the IRGM gene are associated with susceptibility to tuberculosis in humans. A murine ortholog of Irgm , Irgm1 , is also essential for controlling Mycobacterium tuberculosis (Mtb) infection in mice. Multiple processes have been associated with IRGM1 activity that could impact the host response to Mtb infection, including roles in autophagy-mediated pathogen clearance and expa...

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Identifiers and source

Literature Corpus work
b040e226-9762-55e6-99db-b4b4088b9d5b
DOI
10.1101/2023.10.03.560720
Open publication

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Type I IFN signaling in the absence of IRGM1 promotes <i>M. tuberculosis</i> replication in immune cells by suppressing T cell responsesDOI 10.1101/2023.10.03.560720
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