Article

<i>PTEN</i> and <i>ARID1A</i> haploinsufficiency equip colonic epithelium for oncogenic transformation

2024-03-28

Abstract excerpt

Normal aged tissues are thought to exist as a patchwork of mutant clones. However, the relevance of driver mutations in normal tissue in terms of cancer initiation has not been well described. Here, we sought a quantitative understanding of how different cancer drivers achieve an age-related mutational footprint in the human colonic epithelium and to relate the clonal behaviours they generate to cancer risk. Metan...

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Literature Corpus work: a74093bc-9f25-551e-8dc1-e2758f05aff5
DOI: 10.1101/2024.03.27.586939

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