Paired mutation calling and spatial transcriptomics identify cellular neighbourhoods dictating the neoplastic outcome of colitis

Abstract excerpt

<title>Abstract</title> <p>In the progression from Inflammatory Bowel Disease to associated cancer, the clonal mutational landscape shifts from selection of mutations in inflammatory genes to selection of cancer-driver mutations1–4. How prevalence and expansion of either type of mutated clones could be impacted by the cellular environment in which they arise, and how this affects the neoplastic outcome of colitis...

Topics

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• Clonal Evolution
• Colitis
• Colorectal Neoplasms
• Disease Models, Animal
• Gene Expression Profiling
• Mice
• Mutation
• Transcriptome

Identifiers and source

Literature Corpus work

9087d257-ecb3-583a-8c30-f1feea782ef0

DOI

10.21203/rs.3.rs-6401505/v1