Article

Single-crypt evolutionary trajectories of human sporadic and hereditary colorectal precancers

2026-04-14

Abstract excerpt

Our understanding of the earliest genomic processes and evolutionary trajectories that distinguish sporadic from hereditary human cancers remains limited, impeding early diagnosis and risk stratification. Here, we performed whole-genome sequencing of 319 single crypts dissected from normal colorectal mucosa, premalignant polyps and malignant colorectal cancers (CRCs) from five sporadic patients and three familial...

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Literature Corpus work: 832d781b-96ef-5208-b112-fe7144e79957
DOI: 10.64898/2026.04.13.718204

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