Article
Haploinsufficient phenotypes promote selection of PTEN and ARID1A-deficient clones in human colon.
EMBO reports - 1 Mar 2025
Skoufou-Papoutsaki Nefeli, Adler Sam, Mehmed Shenay, Tume Claire, Olpe Cora, Morrissey Edward, Kemp Richard, Girard Anne-Claire, Moutin Elisa B, Chilamakuri Chandra Sekhar Reddy, Miller Jodi L, Lindskog Cecilia, Werle Fabian, Marks Kate, Perrone Francesca, Zilbauer Matthias, Tourigny David S, Winton Douglas J
Abstract excerpt
Cancer driver mutations are defined by their high prevalence in cancers and presumed rarity in normal tissues. However, recent studies show that positive selection in normal epithelia can increase the prevalence of some cancer drivers. To determine their true cancer-driving potential, it is essential to evaluate how frequent these mutations are in normal tissues and what are their phenotypes. Here, we explore the...
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