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Epigenetic loss of heterozygosity of <i>Apc</i> and an inflammation-associated mutational signature detected in <i>Lrig1</i> <sup>+/-</sup> -driven murine colonic adenomas

2019-05-27

Abstract excerpt

Murine colonic adenomas induced by the loss of a single copy of the tumor suppressor gene Apc in Lrig1 +/- expressing progenitor cells grow rapidly, with high penetrance and tumor multiplicity. This study investigates the prevalence of intertumoral genetic heterogeneity and phenotypic variation across tumors, and attempts to identify the genomic cause of the unusual phenotype. Adult Lrig1-CreERT2/+; Apc-flox/+...

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Literature Corpus work
09f7540e-1a1c-5113-8527-a213a79df634
DOI
10.1101/650879
Open publication

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Epigenetic loss of heterozygosity of <i>Apc</i> and an inflammation-associated mutational signature detected in <i>Lrig1</i> <sup>+/-</sup> -driven murine colonic adenomasDOI 10.1101/650879
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