Article

Accumulation of somatic mutations in normal human colonic epithelium

2020-01-01

Abstract excerpt

I investigated stem cell dynamics in normal human colon by detecting somatic variants affecting X-linked and autosomal genes using immunohistochemistry. Applying neutral clonal marks to a large cohort of patients to interpret age-related trends in clone frequencies has established the baseline stem cell dynamics of the tissue. Analysis of a number of new clonal marks showing biased behaviours suggests that differe...

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Literature Corpus work: 17ecc2c7-1755-56f6-a1dd-c84a3761fa89
DOI: 10.17863/cam.48286

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