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Article

Clonal biases dictate availability of colonic cancer driver mutations for transformation.

Nature communications - 16 Apr 2026

Skoufou-Papoutsaki Nefeli, Kemp Richard, Adler Sam, Marks Kate, Girard Anne-Claire, Mehmed Shenay, Lourenço Filipe C, Moutin Elisa B, Ten Hoopen Rogier, Morrissey Edward, Winton Douglas J, Tourigny David S

Abstract excerpt

Aged normal tissues harbour cancer mutations predisposing to transformation. However, how different pro-oncogenic events in the human colon compare in frequency, behaviour and subsequent transformation risk remains unclear. Here, we analyse mutation hotspot regions in five colorectal cancer genes (APC, KRAS, TP53, FBXW7 and CTNNB1) using targeted sequencing of 76,800 normal colonic glands from 56 patients. We...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 41991531
DOI: 10.1038/s41467-026-71944-5
PMCID: PMC13269798

Genes

KRAS
APC
CTNNB1
TP53

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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