Article

Polyclonal origins of human premalignant colorectal lesions

2025-09-12

Abstract excerpt

<h4>ABSTRACT</h4> Cancer is generally thought to be caused by expansion of a single mutant cell 1 . However, analyses of early colorectal cancer lesions suggest that tumors may instead originate from multiple, genetically distinct cell populations 2,3 . Detecting polyclonal tumor initiation is challenging in patients, as it requires profiling early-stage lesions before clonal sweeps obscure diversity. To invest...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 4f0a5c7a-1712-5871-b10d-97c5366eebbe
DOI: 10.1101/2025.09.08.674484

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Polyclonal origins of human premalignant colorectal lesionsDOI 10.1101/2025.09.08.674484Read

Single-crypt evolutionary trajectories of human sporadic and hereditary colorectal precancersSemantic proximity Read

The landscape of somatic mutation in normal colorectal epithelial cellsSemantic proximity Read

Clonal biases dictate availability of colonic cancer driver mutations for transformation.Semantic proximity Read

Colorectal cancer initiation: Understanding early-stage disease for intervention.Semantic proximity Read

The landscape of somatic mutation in normal colorectal epithelial cells.Semantic proximity Read

The earliest stages of neoplastic transformation in Familial Adenomatous PolyposisSemantic proximity Read

Mutational Heterogeneity in APC and KRAS Arises at the Crypt Level and Leads to Polyclonality in Early Colorectal Tumorigenesis.Semantic proximity Read

The Evolutionary Landscape of Colorectal Tumorigenesis: Recent Paradigms, Models, and Hypotheses.Semantic proximity Read

Differential pre-malignant programs and microenvironment chart distinct paths to malignancy in human colorectal polyps.Semantic proximity Read

Early mutational events and clonal dynamics in normal crypts: implications for colorectal tumorigenesis.Semantic proximity Read

Human colorectal pre-cancer atlas identifies distinct molecular programs underlying two major subclasses of pre-malignant tumorsSemantic proximity Read

Many colorectal cancers are "flat" clonal expansions.Semantic proximity Read