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Article

Advances in Colorectal Cancer Cell Biology and Clonal Evolution.

International journal of molecular sciences - 18 Jan 2026

Toghey Sopozme, Harvey-Jones Elizabeth J, Towler Jonathan D, Hafkamp Charlotte J H, Chong Irene Y

Abstract excerpt

Colorectal cancer (CRC) develops through evolutionary processes involving genomic alterations, epigenetic regulation, and microenvironmental interactions. While traditionally explained by the stepwise accumulation of driver mutations, contemporary evidence supports a 'Big Bang' model in which many early-arising clones expand simultaneously to establish extensive heterogeneity. We reviewed recent studies employing...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41596599
DOI: 10.3390/ijms27020953
PMCID: PMC12841925

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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