Article

Massively parallel disruption of enhancers active during human corticogenesis

2019-12-02

Abstract excerpt

Changes in gene regulation have been linked to the expansion of the human cerebral cortex and to neurodevelopmental disorders. However, the biological effects of genetic variation within developmental regulatory elements on human corticogenesis are not well understood. We used sgRNA-Cas9 genetic screens in human neural stem cells (hNSCs) to disrupt 10,674 expressed genes and 2,227 enhancers active in the developin...

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Literature Corpus work: a6f179eb-37f9-5ac0-aa88-b03f61bfcb0a
DOI: 10.1101/852673

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