Article

Early Developmental Origins of Cortical Disorders Modeled in Human Neural Stem Cells

2024-06-14

Abstract excerpt

<h4>ABSTRACT</h4> The implications of the early phases of human telencephalic development, involving neural stem cells (NSCs), in the etiology of cortical disorders remain elusive. Here, we explored the expression dynamics of cortical and neuropsychiatric disorder-associated genes in datasets generated from human NSCs across telencephalic fate transitions in vitro and in vivo. We identified risk genes expressed i...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 6c13c2f9-bb1c-50f1-ad55-f741b1e8f14c
DOI: 10.1101/2024.06.14.598925

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Early Developmental Origins of Cortical Disorders Modeled in Human Neural Stem CellsDOI 10.1101/2024.06.14.598925Read

An integrative single-cell atlas to explore the cellular and temporal specificity of neurological disorder genes during human brain developmentSemantic proximity Read

Chromatin and gene-regulatory dynamics of the developing human cerebral cortex at single-cell resolutionSemantic proximity Read

Chromatin and gene-regulatory dynamics of the developing human cerebral cortex at single-cell resolution.Semantic proximity Read

Variation of human neural stem cells generating organizer states <i>in vitro</i> before committing to cortical excitatory or inhibitory neuronal fatesSemantic proximity Read

Single-cell analysis of prenatal and postnatal human cortical developmentSemantic proximity Read

A single cell transcriptomic analysis of human neocortical developmentSemantic proximity Read

Developmental convergence and divergence in human stem cell models of autism spectrum disorderSemantic proximity Read

Dissecting Gene Regulatory Networks Governing Human Cortical Cell FateSemantic proximity Read

Cell-type-specific 3D epigenomes in the developing human cortex.Semantic proximity Read

<i>DLG2</i> knockout reveals neurogenic transcriptional programs underlying neuropsychiatric disorders and cognitionSemantic proximity Read

Developmental convergence and divergence in human stem cell models of autism.Semantic proximity Read

Dynamic landscapes of gene regulatory networks in early mammalian neurogenesis: Insights into brain evolution and disorder riskSemantic proximity Read