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Article

Chromatin and gene-regulatory dynamics of the developing human cerebral cortex at single-cell resolution.

Cell - 16 Sept 2021

Trevino Alexandro E, Müller Fabian, Andersen Jimena, Sundaram Laksshman, Kathiria Arwa, Shcherbina Anna, Farh Kyle, Chang Howard Y, Pașca Anca M, Kundaje Anshul, Pașca Sergiu P, Greenleaf William J

Abstract excerpt

Genetic perturbations of cortical development can lead to neurodevelopmental disease, including autism spectrum disorder (ASD). To identify genomic regions crucial to corticogenesis, we mapped the activity of gene-regulatory elements generating a single-cell atlas of gene expression and chromatin accessibility both independently and jointly. This revealed waves of gene regulation by key transcription factors...

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PMID: 34390642
DOI: 10.1016/j.cell.2021.07.039

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