Article

Human Accelerated Regions regulate gene networks implicated in apical-to-basal neural progenitor fate transitions

2024-07-01

Abstract excerpt

The evolution of the human cerebral cortex involved modifications in the composition and proliferative potential of the neural stem cell (NSC) niche during brain development. Human Accelerated Regions (HARs) exhibit a significant excess of human-specific sequence changes and have been implicated in human brain evolution. Multiple studies support that HARs include neurodevelopmental enhancers with novel activities...

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Literature Corpus work: 139f6ae3-499f-5646-b0fe-e271b95849d8
DOI: 10.1101/2024.06.30.601407

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