Article

Massively parallel discovery of human-specific substitutions that alter neurodevelopmental enhancer activity

2019-12-05

Abstract excerpt

Genetic changes that altered the function of gene regulatory elements have been implicated in the evolution of the human brain. However, identifying the particular changes that modified regulatory activity during neurodevelopment remains challenging. Here we used massively parallel enhancer assays in human neural stem cells to measure the impact of 32,776 human-specific substitutions on enhancer activity in 1,363...

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Literature Corpus work: 669e0123-d098-536c-ac98-7170ca57669f
DOI: 10.1101/865519

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