Article

Cap-specific second nucleotide ribose methylase CMTR2 is required for transcriptome transition during mammalian germline development

2026-07-29

Abstract excerpt

<h4>SUMMARY</h4> Eukaryotic RNA polymerase II transcripts carry a signature m7G cap (Cap0) structure that is co-transcriptionally added to the 5’ end, and is essential for translation and RNA stability. Higher eukaryotes carry additional essential ribose methylations on the first and second cap-proximal nucleotides, termed as Cap1 and Cap2, respectively. The ubiquitous Cap1 modification protects cellular RNAs fro...

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Literature Corpus work: a6b56df8-e910-5892-a0ab-15035d51e211
DOI: 10.64898/2026.07.28.741271

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