Loss of CMTR1 leads to gastrulation failure and early embryonic lethality.

Abstract excerpt

Cap Methyltransferase 1 (CMTR1) facilitates the addition of a 5' methyl cap on eukaryotic mRNA molecules. Using a knock-out (KO) allele, we demonstrate that CMTR1plays an essential role during gastrulation. In the absence of CMTR1, mutant embryos undergo early lethality, arresting prior to organogenesis with severe developmental delay apparent at E7.5. Multiple molecular approaches indicate significant...

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