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Cap-adjacent 2’- <i>O</i> -ribose methylation of RNA in <i>C. elegans</i> is required for postembryonic growth and germline development in the presence of the decapping exonuclease EOL-1

2025-03-11

Abstract excerpt

<h4>ABSTRACT</h4> Cap-adjacent 2’- O -ribose methylation (cOMe) of the first two transcribed nucleotides of RNA polymerase II transcripts is a conserved feature in many eukaryotes. In mammals, these modifications are key to a transcript surveillance system that regulates the interferon response, but the broader functions of cOMe remain poorly understood. To understand the role of cOMe in C. elegans , we functio...

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Literature Corpus work
396a5e33-de2d-5ab4-86c2-30de52c1dfc6
DOI
10.1101/2025.03.10.638824
Open publication

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Cap-adjacent 2’- <i>O</i> -ribose methylation of RNA in <i>C. elegans</i> is required for postembryonic growth and germline development in the presence of the decapping exonuclease EOL-1DOI 10.1101/2025.03.10.638824
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