Article

Preventing CpG island hypermethylation in oocytes safeguards mouse development

2024-05-31

Abstract excerpt

<h4>SUMMARY</h4> In mammalian somatic and male germline cells, genomes are extensively DNA methylated (DNAme). In oocytes, however, DNAme is largely limited to transcribed regions only. Regulatory CpG-island (CGI) sequences are also devoid of repressive DNAme in somatic and germ cells of both sexes. The mechanisms restricting de novo DNAme acquisition in developing oocytes, at CGIs and globally, and the relevanc...

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Literature Corpus work: 3fa517cd-0c4a-57ff-8eb8-b7dba8917fd5
DOI: 10.1101/2024.05.29.595726

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