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Article

Roles for Drosophila cap1 2'-O-ribose methyltransferase in the small RNA silencing pathway associated with Argonaute 2.

Insect biochemistry and molecular biology - 1 Aug 2020

Lee Seungjae, Hong Jae-Sang, Lim Do-Hwan, Lee Young Sik

Abstract excerpt

Cap1 2'-O-ribose methyltransferase (CMTR1) modifies RNA transcripts containing the 7-methylguanosine cap via 2'-O-ribose methylation of the first transcribed nucleotide, yielding cap1 structures. However, the role of CMTR1 in small RNA-mediated gene silencing remains unknown. Here, we identified and characterized a Drosophila CMTR1 gene (dCMTR1) mutation. We found that the catalytic activity of dCMTR1 was...

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PMID: 32504809
DOI: 10.1016/j.ibmb.2020.103415

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