The rRNA m6A methyltransferase METTL5 is involved in pluripotency and developmental programs.

doi:10.1101/gad.333369.119

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Article

The rRNA m6A methyltransferase METTL5 is involved in pluripotency and developmental programs.

Genes & development - 1 May 2020

Ignatova Valentina V, Stolz Paul, Kaiser Steffen, Gustafsson Tobias H, Lastres Palma Rico, Sanz-Moreno Adrián, Cho Yi-Li, Amarie Oana V, Aguilar-Pimentel Antonio, Klein-Rodewald Tanja, Calzada-Wack Julia, Becker Lore, Marschall Susan, Kraiger Markus, Garrett Lillian, Seisenberger Claudia, Hölter Sabine M, Borland Kayla, Van De Logt Erik, Jansen Pascal W T C, Baltissen Marijke P, Valenta Magdalena, Vermeulen Michiel, Wurst Wolfgang, Gailus-Durner Valerie, Fuchs Helmut, Hrabe de Angelis Martin, Rando Oliver J, Kellner Stefanie M, Bultmann Sebastian, Schneider Robert

Abstract excerpt

Covalent chemical modifications of cellular RNAs directly impact all biological processes. However, our mechanistic understanding of the enzymes catalyzing these modifications, their substrates and biological functions, remains vague. Amongst RNA modifications N6-methyladenosine (m6A) is widespread and found in messenger (mRNA), ribosomal (rRNA), and noncoding RNAs. Here, we undertook a systematic screen to...

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PMID: 32217665
DOI: 10.1101/gad.333369.119
PMCID: PMC7197354

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