Article
Reading and writing of mRNA m6A modification orchestrate maternal-to-zygotic transition in mice
6 Apr 2023
Abstract excerpt
Abstract N 6 -methyladenosine (m 6 A) modification has been shown to regulate RNA metabolism. Here, we investigate m 6 A dynamics during maternal-to-zygotic transition (MZT) in mice through multi-omic analysis. Our results show that m 6 A can be maternally inherited or de novo gained after fertilization. Interestingly, m 6 A modification on maternal mRNAs not only correlates with mRNA degradation, but also...
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