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CMTr mediated 2′-O-ribose methylation status of cap-adjacent nucleotides across animals

15 Aug 2022

Abstract excerpt

Cap methyltransferases (CMTrs) O methylate the 2′ position of the ribose (cOMe) of cap-adjacent nucleotides of animal, protist, and viral mRNAs. Animals generally have two CMTrs, whereas trypanosomes have three, and many viruses encode one in their genome. In the splice leader of mRNAs in trypanosomes, the first four nucleotides contain cOMe, but little is known about the status of cOMe in animals. Here, we show...

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PMID: 35970556
DOI: 10.1261/rna.079317.122

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