Article

MORC2 directs transcription-dependent CpG methylation of human LINE-1 transposons in early neurodevelopment

2025-06-13

Abstract excerpt

<h4>ABSTRACT</h4> Methylation of CpG dinucleotides is essential for silencing genomic repeats such as LINE-1 retrotransposons (L1s) in the germline and soma. Evolutionarily-young L1s are transcribed in human pluripotent stem cells, but how CpG methylation is patterned to these L1s upon exit of pluripotency is unknown. Here we investigate the critical functions of chromatin regulator MORC2 in epigenome reprogrammi...

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Literature Corpus work: 9b56f3b9-24af-5600-9101-251fadf575d7
DOI: 10.1101/2025.06.11.658943

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