Article

The genome-wide, multi-layered architecture of chromosome pairing in early <i>Drosophila</i> embryos

2018-10-17

Abstract excerpt

Genome organization involves cis and trans chromosomal interactions, both implicated in gene regulation, development, and disease. Here, we focused on trans interactions in Drosophila , where homologous chromosomes are paired in somatic cells from embryogenesis through adulthood. We first addressed the long-standing question of whether pairing extends genome-wide and, to this end, developed a haplotype-resolve...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: a6a6c00c-d4f5-5e33-8e17-e22ef2c7a2b2
DOI: 10.1101/443028

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

The genome-wide, multi-layered architecture of chromosome pairing in early <i>Drosophila</i> embryosDOI 10.1101/443028Read

Highly structured homolog pairing reflects functional organization of the <i>Drosophila</i> genomeSemantic proximity Read

Formation of homolog pairing-induced domains in early <i>Drosophila</i> embryo genomeSemantic proximity Read

Somatic chromosome pairing has a determinant impact on 3D chromatin organizationSemantic proximity Read

Pairing of homologous regions in the mouse genome is associated with transcription but not imprinting status.Semantic proximity Read

A global high-density chromatin interaction network reveals functional long-range and trans-chromosomal relationshipsSemantic proximity Read

Stratification of TAD boundaries identified in reproducible Hi-C contact matrices reveals preferential insulation of super-enhancers by strong boundariesSemantic proximity Read

Computational Identification of Genomic Features That Influence 3D Chromatin Domain Formation.Semantic proximity Read

Haplotype-resolved reconstruction and functional interrogation of cancer karyotypesSemantic proximity Read

<i>PRDM9</i> losses in vertebrates are coupled to those of paralogs <i>ZCWPW1</i> and <i>ZCWPW2</i>Semantic proximity Read

Live imaging and biophysical modeling support a button-based mechanism of somatic homolog pairing in <i>Drosophila</i>Semantic proximity Read

A genome-wide screen identifies genes that affect somatic homolog pairing in Drosophila.Semantic proximity Read

Extensive folding variability between homologous chromosomes in mammalian cells.Semantic proximity Read