Article

Stratification of TAD boundaries identified in reproducible Hi-C contact matrices reveals preferential insulation of super-enhancers by strong boundaries

2017-05-24

Abstract excerpt

<h4>ABSTRACT</h4> The metazoan genome is compartmentalized in megabase-scale areas of highly interacting chromatin known as topologically associating domains (TADs), typically identified by computational analyses of Hi-C sequencing data. TADs are demarcated by boundaries that are largely conserved across cell types and even across species, although, increasing evidence suggests that the seemingly invariant TAD bo...

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Literature Corpus work: 6eb149f4-cbd1-572e-a179-a7369db0b43d
DOI: 10.1101/141481

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