Article

Formation of homolog pairing-induced domains in early <i>Drosophila</i> embryo genome

2026-02-06

Abstract excerpt

Somatic homolog pairing is a defining feature of the diploid genome organization in Drosophila and underlies its transvection-based gene regulation. Here, to understand the physical effect of homolog pairing on the resulting three-dimensional (3D) organization, we employ the heterogeneous loop model and reconstruct 3D structures of the Drosophila embryo genome based on its haplotype-resolved Hi-C data. The resul...

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Literature Corpus work: d91f61de-1875-552e-9f13-bb695600a453
DOI: 10.64898/2026.02.04.703931

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