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Article

Extensive folding variability between homologous chromosomes in mammalian cells.

Molecular systems biology - 1 Jul 2025

Irastorza-Azcarate Ibai, Kukalev Alexander, Kempfer Rieke, Thieme Christoph J, Mastrobuoni Guido, Markowski Julia, Loof Gesa, Sparks Thomas M, Brookes Emily, Natarajan Kedar Nath, Sauer Stephan, Fisher Amanda G, Nicodemi Mario, Ren Bing, Schwarz Roland F, Kempa Stefan, Pombo Ana

Abstract excerpt

Genetic variation and 3D chromatin structure have major roles in gene regulation. Due to challenges in mapping chromatin conformation with haplotype-specific resolution, the effects of genetic sequence variation on 3D genome structure and gene expression imbalance remain understudied. Here, we applied Genome Architecture Mapping (GAM) to a hybrid mouse embryonic stem cell (mESC) line with high density of...

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Identifiers

PMID: 40329044
DOI: 10.1038/s44320-025-00107-3
PMCID: PMC12222873

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