Article

Haplotype-resolved reconstruction and functional interrogation of cancer karyotypes

2024-03-06

Abstract excerpt

Genomic characterization has revealed widespread structural complexity in cancer karyotypes, however shotgun sequencing cannot resolve genomic rearrangements with chromosome-length continuity. Here, we describe a two-tiered approach to determine the segmental composition of rearranged chromosomes with haplotype resolution. First, we present refLinker , a new method for robust determination of chromosomal haplotyp...

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Literature Corpus work: a72c063f-3d22-5609-a895-8779784a3f18
DOI: 10.1101/2024.03.02.583108

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