Article

<i>PRDM9</i> losses in vertebrates are coupled to those of paralogs <i>ZCWPW1</i> and <i>ZCWPW2</i>

2021-06-09

Abstract excerpt

In most mammals and likely throughout vertebrates, the gene PRDM9 specifies the locations of meiotic double strand breaks; in mice and humans at least, it also aids in their repair. For both roles, many of the molecular partners remain unknown. Here, we take a phylogenetic approach to identify genes that may be interacting with PRDM9, by leveraging the fact that PRDM9 arose before the origin of vertebrates, but...

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Literature Corpus work: c058a49e-d29c-560f-88e5-495136706bad
DOI: 10.1101/2021.06.08.447603

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