Article
A genome-wide screen identifies genes that affect somatic homolog pairing in Drosophila.
G3 (Bethesda, Md.) - 1 Jul 2012
Bateman Jack R, Larschan Erica, D'Souza Ryan, Marshall Lauren S, Dempsey Kyle E, Johnson Justine E, Mellone Barbara G, Kuroda Mitzi I
Abstract excerpt
In Drosophila and other Dipterans, homologous chromosomes are in close contact in virtually all nuclei, a phenomenon known as somatic homolog pairing. Although homolog pairing has been recognized for over a century, relatively little is known about its regulation. We performed a genome-wide RNAi-based screen that monitored the X-specific localization of the male-specific lethal (MSL) complex, and we identified 59...
Topics
- Alleles
- Animals
- Chromosome Pairing
- Crossing Over, Genetic
- Drosophila
- Drosophila Proteins
- Genome
- Genome-Wide Association Study
- Guanine Nucleotide Exchange Factors
- Histone-Lysine N-Methyltransferase
- In Situ Hybridization, Fluorescence
- Male
- Mutation