Article

Copy number motifs expose genome instability type and predict driver events and disease outcome in breast cancer

2019-09-14

Abstract excerpt

Tumor evolution is dependent on and constrained by the genotypes emerging from genome instability. We hypothesized that non-site-specific copy number motifs would correlate with underlying replication defects and also with tumor and patient fate. Six feature detectors were defined to characterize and score the local spatial behaviour of a copy number profile. By accumulating scores across genomic regions, a low-di...

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Literature Corpus work: a6768061-f3d3-5841-9281-1da247da604f
DOI: 10.1101/769356

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