Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Delineation of the heterogeneity underlying genomic instability in hereditary breast cancers reveals four disease subtypes.

Experimental & molecular medicine - 1 Apr 2026

Kim Sunmin, Lee Seeyoun, Kim Hyeji, Kang Su Jung, Chae Heejung, Kim Bong-Jo, Kong Jinhwa, Kang Min-Chae, Kim Tae-Min, Kong Sun-Young

Abstract excerpt

Hereditary breast cancers (hBCs) exhibit genomic heterogeneity, but their underlying genomic instability and clinical implications remain unclear. We conducted whole-genome sequencing on 129 BRCA1/2-negative hBCs, with subsets analyzed by methylome and transcriptome sequencing, and integrated COSMIC mutational, copy number (CN), and structural variation signatures. We identified four subtypes: homologous...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Breast Neoplasms
Share to DNA Copy Number Variations

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA Methylation

Share to Gene Expression Regulation, Neoplastic

Share to Genetic Heterogeneity

Share to Genomic Instability

Share to Loss of Heterozygosity

Share to Mutation

Source

Open in PubMed Open full text

Identifiers

PMID: 41991965
DOI: 10.1038/s12276-026-01693-4
PMCID: PMC13144627

Genes

BRCA1
GZMA
GZMB

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Delineation of the heterogeneity underlying genomic instability in hereditary breast cancers reveals four disease subtypes.PMID 41991965Read ↗

The somatic mutation profiles of 2,433 breast cancers refines their genomic and transcriptomic landscapes.Semantic proximity Read ↗

Whole-genome landscapes of 1,364 breast cancers.Semantic proximity Read ↗

High Impact Mutation Burden and Integrated Genomic Instability Reveal Subtype-Specific Divergence in Breast CancerSemantic proximity Read ↗

Whole genome sequencing of locally advanced and metastatic breast carcinoma unravels relevant molecular signatures and novel events.Semantic proximity Read ↗

Subtype-specific APOBEC enrichment links genomic instability to predict immunotherapy response in breast cancer subtypes.Semantic proximity Read ↗

Clinical and molecular relevance of mutant-allele tumor heterogeneity in breast cancer.Semantic proximity Read ↗

Regulators of homologous recombination deficiency identified by machine learning using somatic multi-omics data.Semantic proximity Read ↗

Complex rearrangements fuel ER+ and HER2+ breast tumoursSemantic proximity Read ↗

Whole-Genome analyses of 1,364 breast cancers with clinical recordsSemantic proximity Read ↗

Pan-cancer inference of intra-tumor heterogeneity reveals associations with different forms of genomic instabilitySemantic proximity Read ↗

The topography of mutational processes in breast cancer genomes.Semantic proximity Read ↗

Comprehensive Genomic Characterization of Breast Tumors with BRCA1 and BRCA2 MutationsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.