Article
Chromosomal copy number heterogeneity predicts survival rates across cancers.
Nature communications - 27 May 2021
van Dijk Erik, van den Bosch Tom, Lenos Kristiaan J, El Makrini Khalid, Nijman Lisanne E, van Essen Hendrik F B, Lansu Nico, Boekhout Michiel, Hageman Joris H, Fitzgerald Rebecca C, Punt Cornelis J A, Tuynman Jurriaan B, Snippert Hugo J G, Kops Geert J P L, Medema Jan Paul, Ylstra Bauke, Vermeulen Louis, Miedema Daniël M
Abstract excerpt
Survival rates of cancer patients vary widely within and between malignancies. While genetic aberrations are at the root of all cancers, individual genomic features cannot explain these distinct disease outcomes. In contrast, intra-tumour heterogeneity (ITH) has the potential to elucidate pan-cancer survival rates and the biology that drives cancer prognosis. Unfortunately, a comprehensive and effective framework...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.