Whole-genome landscapes of 1,364 breast cancers.

doi:10.1038/s41586-025-09812-3

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Article

Whole-genome landscapes of 1,364 breast cancers.

Nature - 1 Jan 2026

Kim Ryul, Yu Jonghan, Lim Joonoh, Oh Brian Baek-Lok, Nam Seok Jin, Kim Seok Won, Lee Jeong Eon, Chae Byung Joo, Kim Ji-Yeon, Park Ga Eun, Kang Bong Joo, Paik Pill Sun, Bae Soo Yeon, Yoon Chang Ik, Lee Young Joo, Kim Dooreh, Shin Kabsoo, Lee Ji Eun, Kang Jun, Lee Ahwon, Connolly-Strong Erin, Lee Sangmoon, Lee Bo Rahm, Lee Yuna, Yi Ki Jong, Kwon Young Oh, Chun In Hwan, Park Junggil, Kim Jihye, Choi Chahyun, Shin Jong Yeon, Lee Hyungjung, Kim Minji, Park Hansol, Jeong Ilecheon, Yi Boram, Lee Won-Chul, Lee Jeong Seok, Park Woo Chan, Kim Sung Hun, Choi Yoon-La, Lee Jeongmin, Ju Young Seok, Park Yeon Hee

Abstract excerpt

Breast cancer remains a major global health challenge1. Here, to comprehensively characterize its genomic landscape and the clinical significance of genomic characteristics, we analysed whole-genome sequences from 1,364 clinically annotated breast cancers, with transcriptome data available for most cases. Our study expands the repertoire of oncogenic alterations and identifies novel driver genes, recurrent gene...

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PMID: 41339552
DOI: 10.1038/s41586-025-09812-3
PMCID: PMC12851938

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CDK4

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