The genomic and transcriptomic architecture of 2,000 breast tumours reveals novel subgroups.

doi:10.1038/nature10983

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Article

The genomic and transcriptomic architecture of 2,000 breast tumours reveals novel subgroups.

Nature - 18 Apr 2012

Curtis Christina, Shah Sohrab P, Chin Suet-Feung, Turashvili Gulisa, Rueda Oscar M, Dunning Mark J, Speed Doug, Lynch Andy G, Samarajiwa Shamith, Yuan Yinyin, Gräf Stefan, Ha Gavin, Haffari Gholamreza, Bashashati Ali, Russell Roslin, McKinney Steven, Langerød Anita, Green Andrew, Provenzano Elena, Wishart Gordon, Pinder Sarah, Watson Peter, Markowetz Florian, Murphy Leigh, Ellis Ian, Purushotham Arnie, Børresen-Dale Anne-Lise, Brenton James D, Tavaré Simon, Caldas Carlos, Aparicio Samuel

Abstract excerpt

The elucidation of breast cancer subgroups and their molecular drivers requires integrated views of the genome and transcriptome from representative numbers of patients. We present an integrated analysis of copy number and gene expression in a discovery and validation set of 997 and 995 primary breast tumours, respectively, with long-term clinical follow-up. Inherited variants (copy number variants and single...

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PMID: 22522925
DOI: 10.1038/nature10983
PMCID: PMC3440846

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