Novel insights into breast cancer copy number genetic heterogeneity revealed by single-cell genome sequencing.

doi:10.7554/eLife.51480

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Article

Novel insights into breast cancer copy number genetic heterogeneity revealed by single-cell genome sequencing.

eLife - 13 May 2020

Baslan Timour, Kendall Jude, Volyanskyy Konstantin, McNamara Katherine, Cox Hilary, D'Italia Sean, Ambrosio Frank, Riggs Michael, Rodgers Linda, Leotta Anthony, Song Junyan, Mao Yong, Wu Jie, Shah Ronak, Gularte-Mérida Rodrigo, Chadalavada Kalyani, Nanjangud Gouri, Varadan Vinay, Gordon Assaf, Curtis Christina, Krasnitz Alex, Dimitrova Nevenka, Harris Lyndsay, Wigler Michael, Hicks James

Abstract excerpt

Copy number alterations (CNAs) play an important role in molding the genomes of breast cancers and have been shown to be clinically useful for prognostic and therapeutic purposes. However, our knowledge of intra-tumoral genetic heterogeneity of this important class of somatic alterations is limited. Here, using single-cell sequencing, we comprehensively map out the facets of copy number alteration heterogeneity...

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PMID: 32401198
DOI: 10.7554/eLife.51480
PMCID: PMC7220379

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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