Article

Alzheimer’s Disease Risk Allele <i>APOE4</i> Interacts with Arsenic Exposure to Drive Microglial Dysfunction

2026-05-12

Abstract excerpt

<h4>ABSTRACT</h4> Alzheimer’s disease (AD) is influenced by both genetic risk and environmental exposures, but how these factors interact in human microglia remains unclear. Here, we investigate whether the late-onset AD risk allele APOE4 impacts microglial vulnerability to arsenite exposure. To that end, we used CRISPR/Cas9 to generate an isogenic APOE4 +/+ iPSC-derived transcription factor-induced microglia-...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: ab1221e8-df83-5c98-a10e-dad423d16e63
DOI: 10.64898/2026.05.09.723490

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Alzheimer’s Disease Risk Allele <i>APOE4</i> Interacts with Arsenic Exposure to Drive Microglial DysfunctionDOI 10.64898/2026.05.09.723490Read

APOE4 Drives Uniquely Dysfunctional Human Microglial States in Alzheimer’s DiseaseSemantic proximity Read

High throughput identification of genetic regulators of microglial inflammatory processes in Alzheimer’s diseaseSemantic proximity Read

Integrative analysis of pooled CRISPR screens provide functional insights into AD GWAS risk genesSemantic proximity Read

Alzheimer’s disease-linked risk alleles elevate microglial cGAS-associated senescence and neurodegeneration in a tauopathy modelSemantic proximity Read

Heterozygous expression of the Alzheimer’s disease-protective PLCγ2 P522R variant enhances Aβ clearance while preserving synapsesSemantic proximity Read

Microglial transcription profiles in mouse and human are driven by APOE4 and sexSemantic proximity Read

APOE4 confers transcriptomic and functional alterations to primary mouse microglia.Semantic proximity Read

APOE genotype determines cell-type-specific pathological landscape of Alzheimer's disease.Semantic proximity Read

CRISPRi-based screens in iAssembloids to elucidate neuron-glia interactionsSemantic proximity Read

Network dynamics-based subtyping of Alzheimer's disease with microglial genetic risk factors.Semantic proximity Read

Diverse human astrocyte and microglial transcriptional responses to Alzheimer’s pathologySemantic proximity Read

Diverse human astrocyte and microglial transcriptional responses to Alzheimer’s pathologySemantic proximity Read