Back to search

Article

Genetic variability associated with <i>OAS1</i> expression in myeloid cells increases the risk of Alzheimer’s disease and severe COVID-19 outcomes

2021-03-18

Abstract excerpt

Genome-wide association studies of late-onset Alzheimer’s disease (AD) have highlighted the importance of variants associated with genes expressed by the innate immune system in determining risk for AD. Recently, we and others have shown that genes associated with variants that confer risk for AD are significantly enriched in transcriptional networks expressed by amyloid-responsive microglia. This allowed us to pr...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
029c3af8-67c3-59c0-97e4-c05cdb5d76bb
DOI
10.1101/2021.03.16.435702
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Genetic variability associated with <i>OAS1</i> expression in myeloid cells increases the risk of Alzheimer’s disease and severe COVID-19 outcomesDOI 10.1101/2021.03.16.435702
A genetic link between risk for Alzheimer's disease and severe COVID-19 outcomes via the OAS1 gene.Semantic proximity
Long-read transcriptomic identification of synaptic adaptation to amyloid pathology in the <i> App <sup>NL-G-F</sup> </i> knock-in mouse model of the earliest phase of Alzheimer’s diseaseSemantic proximity
Genetic variability in response to amyloid beta deposition influences Alzheimer’s disease riskSemantic proximity
Gene expression and chromatin accessibility comparison in iPSC-derived microglia in African, European, and Amerindian genomes in Alzheimer’s patients and controlsSemantic proximity
High throughput identification of genetic regulators of microglial inflammatory processes in Alzheimer’s diseaseSemantic proximity
Genetics of the human microglia regulome refines Alzheimer’s disease risk lociSemantic proximity
Novel Alzheimer risk genes determine the microglia response to amyloid‐β but not to TAU pathologySemantic proximity
Unveiling the Impact of Microglial Cells in Alzheimer's Disease Pathogenesis: Insights from Single-Cell RNA-seq Analysis and In Vivo ValidationSemantic proximity
Natural genetic variation determines microglia heterogeneity in wild-derived mouse models of Alzheimer’s diseaseSemantic proximity
Comparing Alzheimer's genes in African, European, and Amerindian induced pluripotent stem cell–derived microgliaSemantic proximity
Integration of Alzheimer’s GWAS, 3D genomics, and single-cell CRISPRi non-coding screen implicates causal variants in a microglial enhancer regulating <i>TSPAN14</i>Semantic proximity
Natural genetic variation determines microglia heterogeneity in wild-derived mouse models of Alzheimer's disease.Semantic proximity
Select a neighboring publication to make it the new centre.