Article

INPP5D/SHIP1 regulates inflammasome activation in human microglia

2023-02-26

Abstract excerpt

<h4>ABSTRACT</h4> Microglia and neuroinflammation are implicated in the development and progression of Alzheimer’s disease (AD). To better understand microglia-mediated processes in AD, we studied the function of INPP5D/SHIP1, a gene linked to AD through GWAS. Immunostaining and single nucleus RNA sequencing confirmed that INPP5D expression in the adult human brain is largely restricted to microglia. Examination...

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Literature Corpus work: fe5a798b-4edc-511c-af43-276db5a8e176
DOI: 10.1101/2023.02.25.530025

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