Article

Cryptic Evolution of Heteroresistance as Adaptation to Treatment Interruptions

2026-05-18

Abstract excerpt

The evolution of antibiotic resistance is traditionally understood as a selective sweep to fixation, yielding easily detectable, population-wide resistance. Many clinical isolates, however, exhibit a subtle phenotype in which resistance remains hidden within a susceptible majority despite a clonal genetic background: a phenomenon clinically recognized as heteroresistance (HR). Treatment failure driven by HR has be...

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Literature Corpus work: a5e12885-6e00-529b-b223-5c6fd6993d78
DOI: 10.64898/2026.05.18.725909

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