Article

“Recurrent Extinction of Resistance Mutations Leads to Convergent Multidrug Resistance in Sequential Antibiotic Treatment”

2025-04-09

Abstract excerpt

<h4>Summary</h4> To overcome the antibiotic resistance problem, exploiting reproducible evolutionary tradeoffs is considered key for designing evolution-proof antibiotic therapies. Yet the predictability of resistance evolution has been viewed as limited, given the often idiosyncratic genetic trajectories observed in laboratory evolution experiments. To address this, we partially mimicked clinical antibiotic phar...

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Literature Corpus work: 0eaceb8c-13ad-588b-98ba-c3a73a5cef0d
DOI: 10.1101/2025.04.08.647880

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